徐轶舟;王卓;

• 1:上海交通大学Bio-X研究院遗传发育与精神神经疾病教育部重点实验室

摘要(Abstract)：

基于全基因组规模代谢模型的模拟分析已被成功应用于探索包括癌症在内的多种疾病的发生机制,通过模拟基因敲除对肿瘤细胞生长的影响,鉴别关键代谢重编程节点。通过分析肝细胞肝癌(Hepatocellular carcinoma, HCC)不同于正常肝细胞的代谢差异,发现AKG能够调节肿瘤生长,是潜在的抗癌药物靶点;而TECR在HCC细胞中的重要性降低使其成为潜在的抗肿瘤位点。HCC肝癌细胞在胆固醇合成通路上存在代谢重编程:DHCR24和HMGCS2基因的缺失可以帮助肿瘤细胞避免正常凋亡,而IDI2基因的存在能够增强肿瘤细胞增殖、迁移能力;胆碱代谢物可以影响脂肪酸合成通路从而促进炎症反应来加速癌症发展的进程。

关键词(KeyWords)： 全基因组规模代谢模型;肝细胞肝癌;基因敲除;胆固醇合成;L-氯化棕榈酰肉碱

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划(2017YFC0908105);; 国家自然科学基金面上项目(32070679)

作者(Author): 徐轶舟;王卓;

Email:

DOI:

参考文献(References)：

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