胡春燕;李英文;

• 1:重庆师范大学生命科学学院

摘要(Abstract)：

神经肽Y(NPY)是机体内的一种重要且保守的神经递质,一般以前体形式存在,释放的有活性的NPY主要通过与其受体结合发挥作用。NPY受体包含了亚型Y1、Y2、Y3、Y4、Y5、Y6、Y7、Y8。Y1和Y2是NPY发挥收缩血管作用的关键受体;Y1、Y2和Y5是NPY调节动物摄食行为的关键受体;Y1、Y2和Y4是NPY调控动物焦虑、沮丧行为的必要受体。着重对NPY与其各种受体结合后如何行使动物的相关生理功能的情况进行了阐述。

关键词(KeyWords)： 神经肽Y;神经肽Y受体;生理功能

Abstract:

Keywords:

基金项目(Foundation): 重庆市自然科学基金项目(No.CSTC-2007BB1229)

作者(Author): 胡春燕;李英文;

Email:

DOI:

参考文献(References)：

• [1]曲毅,魏峰涛,方宁远.NPY-Y1受体激动剂对SHR脑血管平滑肌细胞的促增殖作用[J].上海交通大学学报,2006,26:1147-1149.
• [2]Buckwalter J B,Hamann J J,Clifford P S.Neuropeptide Y1 receptorvasoconstriction in exercising canine skeletal muscles[J].ApplPhysiol,2005,99(6):2115-2120.
• [3]Gradin KA,Buus C L,Li J Y,et al.Neuropeptide Y2 receptors areinvolved in enhanced neurogenic vasoconstriction in spontaneouslyhypertensive rats[J].Br J Pharmacol,2006,148(5):703-713.
• [4]Yang K,Guan H,Arany E,et al.Neuropeptide Y is produced invisceral adipose tissue and promotes proliferation of adipocyte precur-sor cells via the Y1 receptor[J].FASEB,2008,22(7):2452-2464.
• [5]晏晓青.神经肽Y调节应激诱导的肥胖[J].中华医学杂志,2007,87(41):2945.
• [6]Lavebratt C,Alpman A,Persson B,et al.Common neuropeptide Y2receptor gene variant is protective against obesity among Swedish men[J].Int J Obes(Lond),2006,30(3):453-459.
• [7]郭锡熔,陈荣华,费莉,等.神经肽Y Y5受体反义寡核苷酸对肥胖大鼠血清胰岛素与C肽水平及脂肪组织TNFα基因mR-NA表达的影响[J].中华儿科杂志,2002,40(11):667-671.
• [8]Balasubramaniam A,Joshi R,Su C,et al.Neuropeptide Y(NPY)Y2 receptor-selective agonist inhibits food intake and promotes fatmetabolism in mice:combined anorectic effects of Y2 and Y4 recep-tor-selective agonists[J].Peptides,2007,28(2):235-240.
• [9]Lin E J,Sainsbury A,Lee N J,et al.Combined deletion of Y1,Y2,and Y4 receptors prevents hypothalamic neuropeptide Y overex-pression-induced hyperinsulinemia despite persistence of hyperphagiaand obesity[J].Endocrinology,2006,147(11):5094-5101.
• [10]Yahya A,Xiao C,Chance W,et al.Up-regulation of neuropeptideY Y4 receptor mRNA expression in the brainstem of refed rats fol-lowing 48 h of food deprivation:effect of leptin[J].Peptides,2006,27(11):2731-2737.
• [11]Heredia Mdel P,Delgado C,Pereira L,et al.Neuropeptide Y rap-idly enhances[Ca2+]i transients and Ca2+sparks in adult rat ven-tricular myocytes through Y1 receptor and PLC activation[J].MolCell Cardiol.2005,38(1):205-212.
• [12]张欣同,唐发宽,董颀,等.神经肽Y1受体激动药诱导大鼠心肌细胞肥大的研究[J].武警医学,2008,19(1):14-16.
• [13]Piao F L,Yuan K,Bai G Y,et al.Different regulation of atrialANP release through neuropeptide Y2 and Y4 receptors[J].KoreanMed Sci,2008,23(6):1027-1032.
• [14]Chen Z Y,Feng G G,Nishiwaki,K,et al.Possible roles of neu-ropeptide Y Y3-receptor subtype in rat aortic endothelial cell prolif-eration under hypoxia,and its specific signal transduction[J].AmJ Physiol Heart Circ Physiol,2007,293(2):59-67.
• [15]王金宝,朱秀娥,刘纪猛,等.大鼠焦虑模型血浆神经肽Y的变化[J].Journal of Medical Forum,2008,29(5):5-7.
• [16]Wheway J,Mackay C R,Newton R A,et al.A fundamental bi-modal role for neuropeptide Y1 receptor in the immune system[J].Exp Med,2005,202(11):1527-1538.
• [17]Nguyen N K,Sartori S B,Herzog H,et al.Effect of neuropeptideY Y2 receptor deletion on emotional stress-induced neuronal activa-tion in mice[J].Synapse,2009,63(3):236-246.
• [18]Painsipp E,Wultsch T,Edelsbrunner M,et al.Reduced anxiety-like and depression-related behavior in neuropeptide Y Y4 receptorknockout mice[J].Genes Brain Behav,2008,7(5):532-542.
• [19]Zwanziger D,Bohme I,Lindner D,et al.First selective agonist ofthe neuropeptide Y1-receptor with reduced size[J].Pept Sci,2009,15(12):856-866.
• [20]Walker MW,Wolinsky TD,Jubian V,et al.The novel neuropep-tide Y Y5 receptor antagonist[N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cycloh exyl]mthyl]methaesuf onamide]exerts anxiolytic-and antidepressant-like effectsin rat models of stress sensitivity[J].Pharmacol Exp Ther,2009,328(3):900-911.
• [21]陈来照.大鼠垂体瘤模型下丘脑中神经肽Y及其受体的表达变化[J].中华实验外科杂志,2007,24(11):1303-1305.
• [22]Smialowska M,Domin H,Zieba B.Neuroprotective effects of neu-ropeptide Y-Y2 and Y5 receptor agonists in vitro and in vivo[J].Neuropeptides,2009,43(3):235-249.